DETERMINE (Defibrillators to Reduce Risk by Magnetic Resonance Imaging Evaluation) is a prospective, multicenter, randomized clinical trials in patients with coronary artery diseases and mild-to-moderate left ventricular dysfunction. The primary objective of the study is to test the hypothesis that implantable cardioverter defibrillator (ICD) therapy in combination with medical therapy, in patients with myocardial infarct greater than or equal to 15% of the left heart muscle mass (as measured by CMR), improves long term survival compared to medical therapy alone. The secondary endpoint is survival from mortality due to the onset of fatal cardiac rhythm disturbances.

The DETERMINE study is based on preliminary work done at Northwestern, Duke, Johns Hopkins Universities and UCLA. This study will determine whether patients with a better reserved ejection fraction (EF) than most ICD patients, but who may represent a greater percentage of patients (due to damage involving greater than or equal to 15% of the left ventricular mass), may benefit from an ICD. At each field center, potential patients will undergo functional cine imaging together with late gadolinium enhancement imaging.


The Cardiac Atlas Project hosts 450 cases from the DETERMINE study, which consists of MR images and some 3D left ventricular models derived semi-automatically by using the CIM software (Cardiac Image Modeller, University of Auckland, NZ).

For images, typical study includes retrospectively gated SSFP cine imaging (typical thickness ≤ 10 mm, gap ≤ 2 mm, TR 30-50 ms, TE 1.6 ms, flip angle 60º, FOV 360 mm, image matrix 128×256, 25 frames, depending on heart rate and breath-hold duration). All cines are acquired during a breath-hold of 8-15 seconds duration. Sufficient short-axis slices will be acquired to cover the whole heart, as well as long-axis slices in the four chamber, two chamber and LV outflow tract views. Late gadolinium enhancement imaging will be performed using segmented spoiled gradient recalled echo imaging with an inversion recovery magnetization preparation, 10 to 20 minutes after intravenous injection of a gadolinium-based contrast agent (0.15 to 0.2 mMol/kg body weight). Delayed enhancement images will be acquired in the same planes and image-slice positions as the cine images.


Daniel C. Lee, MD – Northwestern University, USA


To download the data, you must fill in a specific request with elaborate information about your project. This is required because we need to forward your request to the Data Contributor for a review. Depending on their available (may take >2 weeks), your request can be granted if there is no conflict of interest with their clinical study.

Before filling in the following request, please note that you must abide to the following agreements:

  1. Compliance with the CAP-DETERMINE Data Distribution Agreement.
  2. Publications arising from the work using the DETERMINE data require approval from the DETERMINE publication committee.
  3. DETERMINE requires that all manuscripts using DETERMINE data have one DETERMINE co-author.

If you agree to the above conditions, you may submit the request form below: